Preprint updated October 04, 2023

   We developed a new bioluminescent genetically encoded Ca2+ indicator (GECI), “CaBLAM,” which displays a much higher contrast
(dynamic range) than previously described bioluminescent GECIs coupled with a Ca2+ affinity suitable for
capturing physiological changes in cytosolic Ca2+ concentration.

“CaBLAM consistently generated large changes in BL with ionomycin treatment with a dynamic range 5.4±0.1-fold higher (95% confidenceinterval (95%CI)) than that of GeNL(Ca2+)_480 (Fig. 2A).”

View the preprint on bioRxiv here