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  1. Bright and photostable yellow fluorescent proteins for extended imaging. Nat Commun. 2025 Apr 04; 16(1):3241. Lee J, Lai S, Yang S, Zhao S, Blanco FA, Lyons AC, Merino-Urteaga R, Ahrens JF, Nguyen NA, Liu H, Liu Z, Lambert GG, Shaner NC, Chen L, Tolias KF, Zhang J, Ha T, St-Pierre F. PMID: 40185748; PMCID: PMC11971446.
  2. CaBLAM! A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase. bioRxiv. 2025 Jan 02. Lambert GG, Crespo EL, Murphy J, Boassa D, Luong S, Celinskis D, Venn S, Nguyen DK, Hu J, Sprecher B, Tree MO, Orcutt R, Heydari D, Bell AB, Torreblanca-Zanca A, Hakimi A, Lipscombe D, Moore CI, Hochgeschwender U, Shaner NC. PMID: 37425712; PMCID: PMC10327125.
  3. Toward a brighter constellation: multiorgan neuroimaging of neural and vascular dynamics in the spinal cord and brain. Neurophotonics. 2024 Apr; 11(2):024209. Celinskis D, Black CJ, Murphy J, Barrios-Anderson A, Friedman NG, Shaner NC, Saab CY, Gomez-Ramirez M, Borton DA, Moore CI. PMID: 38725801; PMCID: PMC11079446.
  4. Engineering luminopsins with improved coupling efficiencies. Neurophotonics. 2024 Apr; 11(2):024208. Slaviero AN, Gorantla N, Simkins J, Crespo EL, Ikefuama EC, Tree MO, Prakash M, Björefeldt A, Barnett LM, Lambert GG, Lipscombe D, Moore CI, Shaner NC, Hochgeschwender U. PMID: 38559366; PMCID: PMC10980360.
  5. Efficient opto- and chemogenetic control in a single molecule driven by FRET-modified bioluminescence. Neurophotonics. 2024 Apr; 11(2):021005. Björefeldt A, Murphy J, Crespo EL, Lambert GG, Prakash M, Ikefuama EC, Friedman N, Brown TM, Lipscombe D, Moore CI, Hochgeschwender U, Shaner NC. PMID: 38450294; PMCID: PMC10917299.
  6. Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain. bioRxiv. 2023 Dec 27. Celinskis D, Black CJ, Murphy J, Barrios-Anderson A, Friedman N, Shaner NC, Saab C, Gomez-Ramirez M, Lipscombe D, Borton DA, Moore CI. PMID: 38234789; PMCID: PMC10793404.
  7. A New Highly Efficient Molecule for Both Optogenetic and Chemogenetic Control Driven by FRET Amplification of BioLuminescence. bioRxiv. 2023 Dec 04. Bjorefeldt A, Murphy J, Crespo EL, Lambert GG, Prakash M, Ikefuama EC, Friedman N, Brown TM, Lipscombe D, Moore CI, Hochgeschwender U, Shaner NC. PMID: 37425735; PMCID: PMC10327108.
  8. Engineering luminopsins with improved coupling efficiencies. bioRxiv. 2023 Nov 22. Slaviero A, Gorantla N, Simkins J, Crespo EL, Ikefuama EC, Tree MO, Prakash M, Björefeldt A, Barnett LM, Lambert GG, Lipscombe D, Moore CI, Shaner NC, Hochgeschwender U. PMID: 38045286; PMCID: PMC10690276.
  9. A Bioluminescent Activity Dependent (BLADe) Platform for Converting Neuronal Activity to Photoreceptor Activation. bioRxiv. 2023 Oct 18. Crespo EL, Pal A, Prakash M, Silvagnoli AD, Zaidi Z, Gomez-Ramirez M, Tree MO, Shaner NC, Lipscombe D, Moore C, Hochgeschwender U. PMID: 37425742; PMCID: PMC10327117.
  10. Bioluminescent Genetically Encoded Glutamate Indicators for Molecular Imaging of Neuronal Activity. ACS Synth Biol. 2023 08 18; 12(8):2301-2309. Petersen ED, Lapan AP, Castellanos Franco EA, Fillion AJ, Crespo EL, Lambert GG, Grady CJ, Zanca AT, Orcutt R, Hochgeschwender U, Shaner NC, Gilad AA. PMID: 37450884; PMCID: PMC10443529.
  11. Selective control of synaptically-connected circuit elements by all-optical synapses. Commun Biol. 2022 Jan 11; 5(1):33. Prakash M, Murphy J, St Laurent R, Friedman N, Crespo EL, Bjorefeldt A, Pal A, Bhagat Y, Kauer JA, Shaner NC, Lipscombe D, Moore CI, Hochgeschwender U. PMID: 35017641; PMCID: PMC8752598.
  12. Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife. 2021 Sep 01; 10. Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S. PMID: 34467852; PMCID: PMC8486381.
  13. Bioluminescent optogenetic (BL-OG) activation of neurons during mouse postnatal brain development. STAR Protoc. 2021 Sep 17; 2(3):100667. Crespo EL, Prakash M, Bjorefeldt A, Medendorp WE, Shaner NC, Lipscombe D, Moore CI, Hochgeschwender U. PMID: 34286295; PMCID: PMC8273415.
  14. Local Electric Field Controls Fluorescence Quantum Yield of Red and Far-Red Fluorescent Proteins. Front Mol Biosci. 2021; 8:633217. Drobizhev M, Molina RS, Callis PR, Scott JN, Lambert GG, Salih A, Shaner NC, Hughes TE. PMID: 33763453; PMCID: PMC7983054.
  15. Aequorea's secrets revealed: New fluorescent proteins with unique properties for bioimaging and biosensing. PLoS Biol. 2020 Nov; 18(11):e3000936. Lambert GG, Depernet H, Gotthard G, Schultz DT, Navizet I, Lambert T, Adams SR, Torreblanca-Zanca A, Chu M, Bindels DS, Levesque V, Nero Moffatt J, Salih A, Royant A, Shaner NC. PMID: 33137097; PMCID: PMC7660908.
  16. Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul; 2020:4385-4389. Celinskis D, Friedman N, Koksharov M, Murphy J, Gomez-Ramirez M, Borton D, Shaner N, Hochgeschwender U, Lipscombe D, Moore C. PMID: 33018967.
  17. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Sep 15; 27(18):4013-4029. de Heuvel E, Singh AK, Boronat P, Kooistra AJ, van der Meer T, Sadek P, Blaazer AR, Shaner NC, Bindels DS, Caljon G, Maes L, Sterk GJ, Siderius M, Oberholzer M, de Esch IJP, Brown DG, Leurs R. PMID: 31378593.
  18. Assay for Detecting Gi-Mediated Decreases in cAMP in Living Cells. SLAS Discov. 2018 Oct; 23(9):898-906. Tewson P, Martinka S, Shaner N, Berlot C, Quinn AM, Hughes T. PMID: 29991302.
  19. Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nat Commun. 2018 Apr 30; 9(1):1732. Hong SR, Wang CL, Huang YS, Chang YC, Chang YC, Pusapati GV, Lin CY, Hsu N, Cheng HC, Chiang YC, Huang WE, Shaner NC, Rohatgi R, Inoue T, Lin YC. PMID: 29712905; PMCID: PMC5928066.
  20. Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Sci Rep. 2017 Sep 20; 7(1):11999. Mastop M, Bindels DS, Shaner NC, Postma M, Gadella TWJ, Goedhart J. PMID: 28931898; PMCID: PMC5607329.
  21. Blue-Shifted Green Fluorescent Protein Homologues Are Brighter than Enhanced Green Fluorescent Protein under Two-Photon Excitation. J Phys Chem Lett. 2017 Jun 15; 8(12):2548-2554. Molina RS, Tran TM, Campbell RE, Lambert GG, Salih A, Shaner NC, Hughes TE, Drobizhev M. PMID: 28530831; PMCID: PMC5474692.
  22. Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity. PLoS One. 2017; 12(2):e0171257. Shen Y, Chen Y, Wu J, Shaner NC, Campbell RE. PMID: 28241009; PMCID: PMC5328254.
  23. Structural analysis of the bright monomeric yellow-green fluorescent protein mNeonGreen obtained by directed evolution. Acta Crystallogr D Struct Biol. 2016 Dec 01; 72(Pt 12):1298-1307. Clavel D, Gotthard G, von Stetten D, De Sanctis D, Pasquier H, Lambert GG, Shaner NC, Royant A. PMID: 27917830; PMCID: PMC5137226.
  24. New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories. J Biomol Screen. 2016 Mar; 21(3):298-305. Tewson PH, Martinka S, Shaner NC, Hughes TE, Quinn AM. PMID: 26657040; PMCID: PMC4766961.
  25. Special Section Guest Editorial: Protein Photonics for Imaging, Sensing, and Manipulation: Honoring Prof. Osamu Shimomura, a Pioneer of Photonics for Biomedical Research. J Biomed Opt. 2015 Oct; 20(10):101201. Fujita K, Nagai T, Shaner N, Egner A. PMID: 26527157.
  26. Occurrence of Isopenicillin-N-Synthase Homologs in Bioluminescent Ctenophores and Implications for Coelenterazine Biosynthesis. PLoS One. 2015; 10(6):e0128742. Francis WR, Shaner NC, Christianson LM, Powers ML, Haddock SH. PMID: 26125183; PMCID: PMC4488382.
  27. Fluorescent proteins for quantitative microscopy: important properties and practical evaluation. Methods Cell Biol. 2014; 123:95-111. Shaner NC. PMID: 24974024.
  28. A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum. Nat Methods. 2013 May; 10(5):407-9. Shaner NC, Lambert GG, Chammas A, Ni Y, Cranfill PJ, Baird MA, Sell BR, Allen JR, Day RN, Israelsson M, Davidson MW, Wang J. PMID: 23524392; PMCID: PMC3811051.
  29. A comparison across non-model animals suggests an optimal sequencing depth for de novo transcriptome assembly. BMC Genomics. 2013 Mar 12; 14:167. Francis WR, Christianson LM, Kiko R, Powers ML, Shaner NC, Haddock SH. PMID: 23496952; PMCID: PMC3655071.
  30. Expression and characterization of the calcium-activated photoprotein from the ctenophore Bathocyroe fosteri: insights into light-sensitive photoproteins. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):360-6. Powers ML, McDermott AG, Shaner NC, Haddock SH. PMID: 23262181; PMCID: PMC3570696.
  31. The mFruit collection of monomeric fluorescent proteins. Clin Chem. 2013 Feb; 59(2):440-1. Shaner NC. PMID: 23213078.
  32. Concurrent imaging of synaptic vesicle recycling and calcium dynamics. Front Mol Neurosci. 2011; 4:34. Li H, Foss SM, Dobryy YL, Park CK, Hires SA, Shaner NC, Tsien RY, Osborne LC, Voglmaier SM. PMID: 22065946; PMCID: PMC3206542.
  33. Differential gene expression in the siphonophore Nanomia bijuga (Cnidaria) assessed with multiple next-generation sequencing workflows. PLoS One. 2011; 6(7):e22953. Siebert S, Robinson MD, Tintori SC, Goetz F, Helm RR, Smith SA, Shaner N, Haddock SH, Dunn CW. PMID: 21829563; PMCID: PMC3146525.
  34. The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus. BMC Genomics. 2011 Jan 25; 12:61. Ewen-Campen B, Shaner N, Panfilio KA, Suzuki Y, Roth S, Extavour CG. PMID: 21266083; PMCID: PMC3040728.
  35. A monomeric photoconvertible fluorescent protein for imaging of dynamic protein localization. J Mol Biol. 2010 Sep 03; 401(5):776-91. Hoi H, Shaner NC, Davidson MW, Cairo CW, Wang J, Campbell RE. PMID: 20603133.
  36. Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res. 2010 Mar 15; 70(6):2204-12. Ouyang M, Huang H, Shaner NC, Remacle AG, Shiryaev SA, Strongin AY, Tsien RY, Wang Y. PMID: 20197470; PMCID: PMC2840183.
  37. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem Biol. 2009 Nov 25; 16(11):1169-79. Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. PMID: 19942140; PMCID: PMC2814181.
  38. Improving the photostability of bright monomeric orange and red fluorescent proteins. Nat Methods. 2008 Jun; 5(6):545-51. Shaner NC, Lin MZ, McKeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. PMID: 18454154; PMCID: PMC2853173.
  39. Advances in fluorescent protein technology. J Cell Sci. 2007 Dec 15; 120(Pt 24):4247-60. Shaner NC, Patterson GH, Davidson MW. PMID: 18057027.
  40. Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins. Biochemistry. 2007 May 22; 46(20):5904-10. Ai HW, Shaner NC, Cheng Z, Tsien RY, Campbell RE. PMID: 17444659.
  41. Novel chromophores and buried charges control color in mFruits. Biochemistry. 2006 Aug 15; 45(32):9639-47. Shu X, Shaner NC, Yarbrough CA, Tsien RY, Remington SJ. PMID: 16893165.
  42. A guide to choosing fluorescent proteins. Nat Methods. 2005 Dec; 2(12):905-9. Shaner NC, Steinbach PA, Tsien RY. PMID: 16299475.
  43. Dynamics of Z-band based proteins in developing skeletal muscle cells. Cell Motil Cytoskeleton. 2005 May; 61(1):34-48. Wang J, Shaner N, Mittal B, Zhou Q, Chen J, Sanger JM, Sanger JW. PMID: 15810059; PMCID: PMC1993831.
  44. Actin and alpha-actinin dynamics in the adhesion and motility of EPEC and EHEC on host cells. Cell Motil Cytoskeleton. 2005 Feb; 60(2):104-20. Shaner NC, Sanger JW, Sanger JM. PMID: 15627283.
  45. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol. 2004 Dec; 22(12):1567-72. Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. PMID: 15558047.
  46. Myofibrillogenesis in skeletal muscle cells. Clin Orthop Relat Res. 2002 Oct; (403 Suppl):S153-62. Sanger JW, Chowrashi P, Shaner NC, Spalthoff S, Wang J, Freeman NL, Sanger JM. PMID: 12394464.
  47. Expression of green or red fluorescent protein (GFP or DsRed) linked proteins in nonmuscle and muscle cells. Mol Biotechnol. 2001 Jan; 17(1):65-71. Ayoob JC, Shaner NC, Sanger JW, Sanger JM. PMID: 11280932.

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